New PDF release: Advances in Biology and Therapy of Multiple Myeloma: Volume
By Esteban Braggio Ph.D., Rafael Fonseca M.D. (auth.), Nikhil C. Munshi, Kenneth C. Anderson (eds.)
Despite the advances in traditional, novel agent and excessive dose chemotherapy a number of myeloma (MM) continues to be incurable. so one can triumph over resistance to present cures and increase sufferer end result, novel biologically-based therapy methods are being built. present translational learn in MM concentrating on the improvement of molecularly-based mixture remedies has nice promise to accomplish excessive frequency and sturdy responses within the majority of sufferers. significant advances are making this target attainable. First, fresh advances in genomics and proteomics in MM have allowed for elevated knowing of affliction pathogenesis, pointed out novel healing pursuits, allowed for molecular class, and supplied the clinical intent for combining specified treatments to extend tumor phone cytotoxicity and abrogate drug resistance. moment, there's now an elevated knowing of ways adhesion of MM cells in bone marrow (BM) extra affects gene expression in MM cells, in addition to in BM stromal cells (BMSCs). because of those advances in oncogenomics at the one hand and elevated knowing of the function of the BM within the pathogenesis of MM at the different, a brand new remedy paradigm concentrating on the tumor telephone and its BM microenvironment to beat drug resistance and increase sufferer end result has now been constructed. Thalidomide, lenalidomide, and Bortezomib are 3 brokers which goal the tumor cellphone in its microenvironment in either laboratory and animal versions and that have speedily translated from the bench to the bedside. Ongoing efforts are utilizing oncogenomics and mobile signaling reports to spot subsequent new release of treatments in MM at the one hand, and to notify the layout of blend trials at the different. This new paradigm for overcoming drug resistance and enhancing sufferer final result in MM has nice promise not just to alter the average background of MM, but in addition to function a version for certain therapeutics directed to enhance final result of sufferers with MM.
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Extra resources for Advances in Biology and Therapy of Multiple Myeloma: Volume 1: Basic Science
Desikan R, Barlogie B, Sawyer J et al (2000) Results of high-dose therapy for 1000 patients with multiple myeloma: durable complete remissions and superior survival in the absence of chromosome 13 abnormalities. Blood 95:4008–4010 73. Zojer N, Konigsberg R, Ackermann J et al (2000) Deletion of 13q14 remains an independent adverse prognostic variable in multiple myeloma despite its frequent detection by interphase ﬂuorescence in situ hybridization. Blood 95:1925–1930 74. Fonseca R, Harrington D, Oken MM et al (2002) Biological and prognostic signiﬁcance of interphase ﬂuorescence in situ hybridization detection of chromosome 13 abnormalities (delta13) in multiple myeloma: an eastern cooperative oncology group study.
Blood 101:2374–2376 48. Moreau P, Attal M, Garban F et al (2007) Heterogeneity of t(4;14) in multiple myeloma. Longterm follow-up of 100 cases treated with tandem transplantation in IFM99 trials. Leukemia 21:2020–2024 49. Avet-Loiseau H, Leleu X, Roussel M et al (2010) Bortezomib Plus Dexamethasone Induction Improves Outcome of Patients With t(4;14) Myeloma but Not Outcome of Patients With del(17p). J Clin Oncol 28(30):4630–4634 50. Chesi M, Bergsagel PL, Shonukan OO et al (1998) Frequent dysregulation of the c-maf proto-oncogene at 16q23 by translocation to an Ig locus in multiple myeloma.
Samples can be sent to a reference lab, enabling a huge improvement in cost-effectiveness, and also high reproducibility. So FISH karyotyping is probably the method of choice for the analysis of chromosomal changes in myeloma. Combining Inﬂuence of t(4;14), del(17p), along with beta 2-microglobulin level may provide a superior model to predict overall survival (Fig. 3). 4 Genomic Abnormalities in MM Genome-wide CGH and SNP DNA arrays have demonstrated their utility to identify acquired chromosome abnormalities in myeloma cells [1, 2, 62–69].
Advances in Biology and Therapy of Multiple Myeloma: Volume 1: Basic Science by Esteban Braggio Ph.D., Rafael Fonseca M.D. (auth.), Nikhil C. Munshi, Kenneth C. Anderson (eds.)