Advances in Genetics, Vol. 34 by Jeffrey C. Hall, Jay C. Dunlap (Eds.) PDF

By Jeffrey C. Hall, Jay C. Dunlap (Eds.)

ISBN-10: 0120176343

ISBN-13: 9780120176342

This quantity of Advances in Genetics illustrates the sequence objective to put up the most up-tp-date, up to date stories within the box of molecular and human genetics. This quantity deviates from earlier volumes in that it focuses exclusively at the polytene chromosome. In an exceptional and exhaustive evaluate, I.F. Zhimulev illustrates the use and serve as of the polytene chromosome in 3 components: morphology and constitution, association and useful function of the heterochromaticregions, and the transcription styles and replication of the chromosome. To top illustrate the breadth and scope of study, Dr. Zhimulev contains greater than a hundred figures and greater than 2900 references in particular appropriate to the polytene chromosome. Key positive aspects * offers technical and old overviews of molecular biology utilized to disorder detection, prognosis, and therapy * Chronicles the continued explosion of data in molecular genetic drugs by means of highlighting present methods to realizing human disease * records the revolution in human and molecular genetics resulting in a brand new box of medication

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Extra info for Advances in Genetics, Vol. 34

Example text

Interestingly, several reports now indicate that deficiencies in these surveillance mechanisms may underlie the increase in aneuploidy associated with human oocytes from older women (Hassold and Hunt 2001). 3 Methods for Assessing Genomic Integrity At present, most methods used to detect genomic integrity rely upon traditional chromosome spreads and karyotyping, although the increased adoption of both FISH and more recently comparative genomic hybridization has both materially extended the resolution and clinical utility for studying this problem (Dyson et al.

EMBO Rep 3(3):230–234 Mattson BA, Albertini DF (1990) Oogenesis: chromatin and microtubule dynamics during meiotic prophase. Mol Reprod Dev 25(4):374–383 Meirow D (2000) Reproduction post-chemotherapy in young cancer patients. Mol Cell Endocrinol 169(1–2):123–131 Moir RD, Spann TP, Herrmann H et al (2000) Disruption of nuclear lamin organization blocks the elongation phase of DNA replication. J Cell Biol 149(6):1179–1192 Santos F, Hendrich B, Reik W et al (2002) Dynamic reprogramming of DNA methylation in the early mouse embryo.

2005). Moreover, superimposed on the chromatin-intrinsic and highly regulated changes in chromatin that occur during the cell cycle, differentiation, or death for that matter, are so-called epigenetic modifications such as DNA methylation and posttranslational alterations in chromatin-associated proteins. Many recent reviews have covered these topics in detail (Bromfield et al. 2008; Santos et al. 2002). More to the point of this chapter are the unique attributes of the mammalian oocyte that make the regulation of its genetic integrity central to the field of fertility preservation (Adriaens et al.

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Advances in Genetics, Vol. 34 by Jeffrey C. Hall, Jay C. Dunlap (Eds.)


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