Advances in Heterocyclic Chemistry, Vol. 54 by Alan R. Katritzky (Ed.) PDF

By Alan R. Katritzky (Ed.)

ISBN-10: 0120207540

ISBN-13: 9780120207541

(from preface)Volume fifty four of Advances in HeterocycUc Chemistry is a monograph quantity, i.e., it really is dedicated to a unmarried topic, the aminomethylenemalo-nates.Aminomethylenemalonates are of serious value in heterocyclic synthesis and feature been utilized in the education of a truly wide array of heterocycles. The chemistry of this crew of compounds has no longer been reviewed in additional than 50 years. the current remedy by way of Istvln Hermecz and associates, Geza Kareszturi and Lelle Vasv^ri-Debreczy. presents a entire overview.After an introductory part, paintings from the nineteenth century is in short thought of and next sections talk about in flip the constitution and physicochemical homes of the aminomethylenemalonates, theirprepa-ration, and, within the biggest sections, the applying of the aminomethylenemalonates to heterocyclic synthesis...

Show description

Read or Download Advances in Heterocyclic Chemistry, Vol. 54 PDF

Similar organic books

Download e-book for kindle: The chemistry of phenols by Zvi Rappoport

Phenols are found in a wide selection of common items. They function anti-oxidants, artificial intermediates, are acidic, shape polymers and hydrogen bonds, and endure a large choice of reactions. This quantity covers all points of phenol chemistry, fromn normal and theoretical features, structural chemistry, MS, NMR, IR/UV to artificial elements in vitro and vivo.

New PDF release: Organic Chemistry in Action: The Design of Organic Synthesis

The 1st version of this booklet was once welcomed with nice enthusiasm by way of academics and scholars. It accordingly appeared opportune to put up a moment, revised, up to date and prolonged variation. regrettably, Professor Fèlix Serratosa died earlier than he may well entire this activity. a few new fabric has been extra, the extra major alterations being:1) The ebook has been restructured into well-differentiated sections: half A, facing traditional natural synthesis, and half B, committed completely to computer-assisted natural synthesis and in line with the previous bankruptcy eleven and Appendices 2, three and four of the 1st version.

Toxic Organic Chemicals in Porous Media - download pdf or read online

In March, 1983 a workshop on toxins in Porous Media was once hosted through the Institute of Soils and Water of the rural study Organi­ zation in guess Dagan, Israel. At this workshop, the unsaturated region be­ tween the soil floor and groundwater was once the point of interest of discus­ sions for scientists from a variety of disciplines reminiscent of soil chemists, physicists, biologists and environmental engineers.

Jianxian Gong's Total Synthesis of (±)-Maoecrystal V PDF

During this thesis, the writer describes the entire synthesis of usual product Maoecrystal V intimately. within the first a part of the thesis, the writer introduces the study heritage and reports the study development in overall synthesis of Maoecrystal V. within the moment half, the writer develops a singular and concise strategy for the stereo selective building of the tetracyclic version procedure of Maoecrystal V.

Additional info for Advances in Heterocyclic Chemistry, Vol. 54

Sample text

77JHC621) have been used. , triethylamine in methanol (68MIl)l. , 46JA1232, 46JA1268, 46JA1317; 5OJCS464, 50JOC1224; 58JCS828; 70CPB1385). The most frequently applied dialkyl alkoxymethylenemalonate is EMME. , 75JAP(K)49286; Sec. , 74MIPI ; 76ACH91). , 52LA48) are also sometimes used (Scheme 7). , 76JCS(P1)1331]. , 75IJC 1275)(Scheme 8). , 64JMC68, 64JMC487; 70CPB1385; 77GEP2612314; 78GEP2737542). Both 2-nitroaniline and N-methylaniline react less readily than aniline with EMME, but if these two groups are present at the same time (N-methyl-2-nitroaniline was used), no reaction occurred at all (59JCS2401) (Scheme 9).

FROMAMINES A N D DIALKYL 1-ALKOXYALKYLIDENEMALONATES The reactions of amines and dialkyl alkoxymethylenemalonates are most frequently used to prepare the aminomethylenemalonates. Dialkyl alkoxymethylenemalonates react smoothly with amines under a wide variety of reaction conditions, usually with high yields (Scheme 6). The reactions probably proceed by an addition-elimination mechanism. In some cases, the addition products have been successfully isolated. 4-triazole was reacted with diethyl ethoxymethylenemalonate (EMME) in aqueous ethanol at ambient temperature for two days, an addition product (24) was obtained in 38% yield instead of a condensation product (62JCS2222).

4-Amino-2,2,6,6-tetramethylpiperidine was reacted with EMME in ethanol at ambient temperature to yield (4-piperidiny1amino)methylenemalonate (36)(77GEP2612314). Sec. A. I ] 25 SYNTHESES and diThe reaction of methyl 2-amino-2-deoxy-a-~-glucofuranoside methyl methoxymethylenemalonate in water for 5 h gave aminomethylenemalonate (37) in 92% yield (87MI4). + %OMe NHZ 500Me MeOCH=$ water COOMe On reaction with EMME in methanol at ambient temperature, glycosylamines gave N-glycosylaniinomethylenernalonates(38)in 8-44% yields was pre(68MI 1).

Download PDF sample

Advances in Heterocyclic Chemistry, Vol. 54 by Alan R. Katritzky (Ed.)


by Charles
4.0

Rated 4.30 of 5 – based on 35 votes