Alzheimer’s Disease: Lessons from Cell Biology - download pdf or read online
By E. Grote, F. Bonzelius, G. Herman (auth.), K. S. Kosik M.D., D. J. Selkoe M.D., Y. Christen Ph.D. (eds.)
Like the unflinching gaze of Captain Ahab strolling the deck of the Pequod, Alzheimer researchers have had their attractions fastened firmly at the ailment for a few years. Now, as this quantity amply demonstrates, finished researchers from different fields, who've suggestion deeply approximately phone organic difficulties are making use of their insights to Alzheimer's affliction. The contri butions the following signify the textual content types of the complaints from the 10th "Colloque medecine et recherche" of the Fondation IPSEN dedicated to learn on Alzheimer's affliction. The symposium, entitled "Alzheimer's illness: classes from mobilephone Biology" used to be held in Paris on April 25, 1994. As is obvious from the various backgrounds of the participants, the clinical pursuit of Alzheimer's sickness has began to meld with extra easy disciplines, quite mobilephone biology. whereas at the one hand, new parts of specialization are always rising, the limits of older disciplines are increas ingly blurred. probably for many of the years because the first descriptions of the affliction in 1907, the technological know-how of Alzheimer's sickness used to be descriptive, and lay within the province of pathologists. this period of time, in which greatly used to be realized concerning the topography of senile plaques and neurofibrillary tangles, culminated with an ultrastructural description of those hallmark constructions. the trendy period of Alzheimer's disorder examine opened with the iden tification of the part proteins in plaques and tangles.
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Additional resources for Alzheimer’s Disease: Lessons from Cell Biology
Thus, cells seem to have the capacity to induce the coordinate synthesis of a group of organelle-specific proteins. MPRs cycle between the TGN and late endosomes in what is referred to as the biosynthetic pathway, and between the cell surface and early endosomes along the conventional endocytic pathway (Fig. 1). These pathways are interconnected, in that the entire pool of MPRs cycles through the cell surface in less than an hour. However, it has not yet been established precisely how these pathways are connected.
It is most likely that the P-APP is delivered directly from the trans Golgi network (TGN) to the cell surface. Moreover, work from many labs suggests that P-APP undergoes a cycle of internalization and recycling, most likely through the early endosome and perhaps also the late endosomes. Some P-APP may be degraded within late endosomes. Only a small percentage of total membrane proteins is transported from late endosomes to the TGN. This group includes the mannose 6-phosphate receptor, which delivers newly synthesized lysosomal enzymes from the TGN to the endocytic pathway.
These cells expressed rab9 S21N protein at approximately two-fold higher levels than the endogenous, wild type rab9 protein. We used an assay devised by Kornfeld and colleagues to detect the transport of proteins from the cell surface to the TGN in living cells (Duncan and Kornfeld 1988). Metabolically labeled surface MPRs were de-sialylated by incubation of cells with neuraminidase at 37°C. Under these conditions, a large proportion of MPRs cycle through the surface, where they can be acted upon by the neuraminidase.
Alzheimer’s Disease: Lessons from Cell Biology by E. Grote, F. Bonzelius, G. Herman (auth.), K. S. Kosik M.D., D. J. Selkoe M.D., Y. Christen Ph.D. (eds.)