Biology of Renal Cell Carcinoma by Ronald M. Bukowski M.D., James H. Finke Ph.D., Eric A. Klein PDF
By Ronald M. Bukowski M.D., James H. Finke Ph.D., Eric A. Klein M.D. (auth.)
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Extra info for Biology of Renal Cell Carcinoma
First, they had to be expressed in VHL disease target organs such as kidney, brain, and adrenal. Second, the candidate disease gene should contain mutations that are transmitted through the germline and co-segregate with the disease. One cDNA, termed g6, was identified from the telomeric end of cosmid 11 and was shown to be expressed in appropriate tissues by northern blotting. However, no mutations were found in the g6 gene in 120 VHL patients analyzed (18). Additionally, g6 was found to cross-react to a locus on chromosome Xp22 (F.
LatifF, Tory K, Gnarra I, et al. Identification of the von Rippel-Lindau disease tumor suppressor gene. ) 260: 1317-1320, 1993. 42. Yamakawa K, Morita R, Takahashi E, Rori T, Ishikawa J, Nakamura Y. A detailed deletion mapping of the short arm of chromosome 3 in sporsdic renal cell carcinoma. Cancer Res 5 1: 47074711, 1991. 43. Morita R, Saito S, Ishikawa I, et al. Common regions of deletion on chromosome 5q, 6q, and IOq in renal cell carcinoma. Cancer Res 51: 5817-5820, 1991. 4 Molecular Studies of the VHL Tumor Suppressor Gene in Renal Cell Carcinoma JamesR.
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Biology of Renal Cell Carcinoma by Ronald M. Bukowski M.D., James H. Finke Ph.D., Eric A. Klein M.D. (auth.)